A form of arthritis, occurring mainly in people, over the age of 45, that is characterized by chronic degeneration, or "wear and tear", of the cartilage of the joints. Also called degenerative joint disease. It is the most common form of arthritis; about 20 million people in the US have osteoarthritis. OA usually affects more females than males, people with a family history of OA and people with other types of arthritis and people who are obese.Back to Top
Men and Women at least 40 years of age.Back to Top
There are approximately 80 centers in the United States that are helping to conduct this study.Back to Top
If you pass this initial screener, a member of a study doctorís staff will contact you -- they will ask you more questions to further assess if you should participate in this study. If they believe that you should be considered, you will be asked to schedule an appointment at the doctorís office (or clinic) for further evaluations. When you go to the doctorís office, the study doctor and his/her team conduct study related examinations and tests to see if you can be enrolled into this study.Back to Top
Each personís participation will be 32-45 days During that time, participants will need to visit the research site 6 times.Back to Top
The purpose of this study is to evaluate the effectiveness and safety of an investigational drug in patients with osteoarthritis of the knee.Back to Top
If you qualify for the study and decide to participate, there is a chance that you will only receive placebo, an inactive medication. This is a random process (like a flip of a coin) -- neither you nor your study doctor will know which treatment you receive.Back to Top
The qualified study physician will discuss the potential risks and benefits of this investigational treatment and review the possibility of experiencing any side effects associated with this study medication before you begin the actual study.Back to Top
No, but you may contact your personal physician or you may give the study doctor permission to contact your personal physician.Back to Top
The call is being recorded for quality assurance purposes. Also, if you are a resident of California, the California law SB 1633 requires a recording of the entire conversation whenever a business requests medical information directly from an individual. California law also requires us to keep the recording for three years after the conversation date. The audio recording will be kept in a secure location and will not be shared without your permission or except if required by law.Back to Top
Any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream.Back to Top
Arteriosclerosis, angina, high blood pressure, high cholesterol, heart attack, stroke, arrhythmia and heart disease.Back to Top
Heart failure simply means that the heart is not pumping blood through the body as well as it should. As the heart's pumping action weakens, blood backs up into the blood vessels around the lungs and causes seepage into the lungs. The fluid causes congestion and makes it hard to breathe. Many people with heart failure also have swollen legs and feet. That is why heart failure is sometimes called congestive heart failure.Back to Top
Damage to the heart muscle due to insufficient blood supply.Back to Top
Hepatitis is an inflammation of the liver, which may be caused by a bacterial or viral infection, parasitic infestation, alcohol, drugs, toxins, or transfusion of incompatible blood. Although many cases of hepatitis are not a serious health threat, the disease can become chronic and sometimes lead to liver failure and death.Back to Top
HIV is a viral infection that gradually destroys the immune system. It is passed from person to person through bodily fluids.Back to Top
A hysterectomy is an operation to remove the uterus (womb).Back to Top
A disease affecting the kidneys, especially one that requires dialysis. Dialysis is the use of an artificial kidney machine required to keep a person alive.Back to Top
An inhaler is a medical device used for delivering medication into the body via the lungs. It is often used in the treatment of asthmaBack to Top
A disease affecting the liver, such as hepatitis B and hepatitis C.Back to Top
Menopause is when menstruation permanently stops.Back to Top
A form of arthritis, occurring mainly in older persons, that is characterized by chronic degeneration (wear and tear) of the cartilage of the joints. Also called degenerative joint disease.Back to Top
Removal of the ovaries.Back to Top
Inflammation of the pancreasBack to Top
A degenerative disorder of the central nervous system that often impairs the sufferer's motor skills and speech.Back to Top
Placebo is an inactive substance or preparation used as a control in an experiment or test to determine the effectiveness of a medicinal drug.Back to Top
Rheumatoid arthritis is a form of arthritis in which the membranes or tissues lining the joints become inflamed (synovitis). Joint inflammation causes swelling and pain and, over time, may destroy the joint tissues and lead to disability.Back to Top
The loss or alteration of bodily function that results from an insufficient supply of blood to part of the brain is called a stroke.Back to Top
A method of female sterilization in which the fallopian tubes are tied during a surgical operation.Back to Top
The online screening questionnaire asks a series of relevant health-related questions and compares the responses to the enrollment criteria for this clinical research study to help determine your eligibility to participate in a specific research study.Back to Top
If you are unsure about a particular question or do not understand what you are being asked, please select the appropriate help topic link. The Help and Synopsis buttons will always be available if you have questions or concerns while completing the questionnaire. We encourage you to discuss any detailed medical questions with your physician or other healthcare provider. You may also contact us by email or call the toll-free number, which was provided in the message that you received, to complete the screening questionnaire by telephone. Our call center operators are available every weekday between 8 a.m. and 10 p.m. (Eastern time).Back to Top
The length of time required to complete the online screening questionnaire will vary from person to person and may also vary depending on the speed of your Internet connection or browser. For your convenience a progress bar located at the bottom of the page indicates your relative position within the survey, which can be used as an indicator of the length of time remaining until the questionnaire will be complete.Back to Top
While completing the online screening questionnaire, please always use the Next and Back buttons provided at the bottom of the screen to move forward and backward through the questionnaire. Please DO NOT use your Internet browser's FORWARD and BACK buttons.
After completing a question, select the Next button to move to the next question; select the Back button to move to a previous question.
The Help and Synopsis buttons will always be available if you have questions or concerns while completing the questionnaire.Back to Top
If you would like to revise a response, select the back button to navigate to that question and revise as necessary.
Please note, however, that the series of questions may change based on any revisions you make to your responses. Therefore, if you revise any response, you will need to recheck your responses for the subsequent questions.Back to Top
If your responses establish that you passed the initial screening for this research study, you will be asked to select from a list of convenient research locations. Your completed questionnaire will then be forwarded to the research location that you choose, and a member of the research study staff there will contact you to schedule an appointment.Back to Top
Once you have clicked on the Submit button and have reached our "Thank you" page, you can follow the link on that page to the Acurian Web site, or you can simply use one of your bookmarks or type in a URL to go to another site on the Internet.Back to Top
We encourage you to discuss any detailed medical questions with your physician or other healthcare provider. You may also contact us by email if you have questions about completing the online screening questionnaire.Back to Top
Unfortunately, we occasionally experience technical problems with our servers or online screening questionnaires. From time to time, our servers may become overloaded when too many people try to access a questionnaire at the same time. If you can't access the questionnaire or it takes too long to complete a particular survey, you can always complete the questionnaire at a later time.
If you are experiencing a technical problem, please feel free to contact us by email or call the toll-free number, which was provided in the message that you received, to complete the screening questionnaire by telephone. Our call center operators are available every weekday between 8 a.m. and 10 p.m. (Eastern time).Back to Top
We recommend using Internet Explorer 5.0 (or subsequent releases) to view our online screening questionnaires. We also encourage AOL users to use the non-AOL version of Internet Explorer when completing our questionnaires because it produces a faster connection and a better overall experience. For your convenience, here is a link to the download of the latest version of Internet Explorer:
All you need is an Internet browser (please see Which browser works best?) and an Internet connection to complete the online screening questionnaire.Back to Top
A clinical research trial, or research study, involves volunteers and is conducted by qualified physicians to evaluate an investigational treatment for a specific disease or group of diseases. Before the investigational drug is given to participants in a clinical research trial, it is researched in the laboratory. Clinical research studies provide an effective way to test investigational medicines. All FDA regulated products in widespread use today had to be proven effective and safe in clinical studies, before they could be marketed.Back to Top
Most eligible volunteers enroll in a clinical research trial because they hope that they will personally benefit from the study-related investigational drug or treatment they receive, or because they want to help advance medical science, believing they can help other individuals who may some day benefit from what is learned in the research study. However, there may be no benefits promised if you elect to participate. The research study doctor will discuss the potential risks and benefits with you.
You will be presented with an Informed Consent form that every research study participant must understand and sign before enrolling into the research study. The Informed Consent lists -- in detail -- the most common known risks and side effects of the investigational drug.Back to Top
Yes. Participants should see their family doctor for routine medical care.Back to Top
We encourage you to talk with the research study doctor about how he/she will involve and/or inform your personal physician. This will only be done with your permission.Back to Top
Your responses to the screening questions will be compared to the enrollment criteria for this clinical research study to help determine your eligibility to participate in the research study.
We need to ensure that we are able to provide the most up-to-date personal information and contact information available to the research site that you choose if your responses establish your eligibility to participate in this research study. The research site will need to contact you as quickly as possible to schedule an appointment and will also need to provide any special instructions that might be necessary or helpful for that appointment and any subsequent office visits.
Acurian is a company that helps potential research study volunteers and caregivers find doctors who are conducting research studies. In this way, Acurian helps to speed up the research process for new investigational medicines. For more information about Acurian and clinical research studies, visit their web site at www.acurian.com.Back to Top
If you have comments, suggestions, or concerns about the online screening questionnaire, please feel free to contact us.Back to Top
We encourage you to discuss any specific medical questions with your physician or other healthcare provider. Your doctor or other healthcare professional is the best source of information to answer your questions.Back to Top
I'm sorry but I am unable to give you the specific reason why you did not pass the initial screening for this research study. The computer program I use determines whether or not you pass this initial screening and it does not allow me to see the details. Individuals qualify or disqualify based on the research study's criteria, which are set up to protect potential participants and answer specific research questions.Back to Top
If your letter has a website address that includes your name, do not be alarmed. The website does not actually exist as a webpage. It is simply an address to grab your attention, and when you type it into your web browser, it simply goes to the www.acuriantrials.com website. It is not indexed in any search engines because it is considered a "virtual" (not real) web address. To see for yourself, just type the address into your web browser. Acurian uses the personalized web addresses because it helps to increase the number of people who respond to the letter. Other companies have similar techniques, such as sport uniform companies that print a personís last name on the picture of a football jersey that is for sale in a catalog.Back to Top
After you have read these instructions, please close this window to return the online screening questionnaire.